Molecular Design & Synthesis Group

Molecular Design & Synthesis Group

Specialist Research Groups

Group is involved the design of new molecules with specific applications, and their synthesis. In most cases, molecules of biological relevance are targeted, particularly as new human and/or veterinary therapeutics. The main emphasis is on antimicrobial compounds in order to address the global Antimicrobial Resistance crisis. Small molecules, antimicrobial peptides, as well as their metal-based analogues, are the main synthetic targets at present. Research is now also targeting food applications including food preservation and stabilisation.This is a specialist group within the larger Centre of Applied Science for Health.

Personnel: 
PI Names:
                                     
Dr Fintan Kelleher (lead)               
Dr Adrienne Fleming                     
Dr Mary Deasy                              
Dr Bernie Creaven                          
Dr Ed Carey                                  
Dr Brian Murray                            
                                                      
Research Assistant:                   
Célia Brahmia

Postgraduate Research Students (Currently):
Agnieszka Wądołowska
Jordan Magtaan
Wayne Travers
Dean Winder
Keith Byrne
Gemma Newman
Holly Jenkins
Ronan McAteer

Projects and Programmes funded (in total >€12M) by Science Foundation Ireland; Irish Research Council; Enterprise Ireland Commercialisation Fund; Programme for Research in Third Level Institutions – HEA; Technological Sector Research Strands III and I; Institutes of Technology Ireland; IT Tallaght President’s Research Award Programme.

National
Professors Colin Hill & Paul Ross – SFI funded APC Microbiome Institute, UCC; Professor Marc Devocelle, RCSI; Dr Goar Sánchez-Sanz, Irish Centre for High-End Computing (ICHEC); Professor Fiona Regan, DCU; Professor Michael Devereux, DIT; Dr. Orla Howe, DIT; Dr. Andrew Kellett, DCU; Prof. Matthias Tacke, UCD; Prof. Siobhan McClean, UCD
Dr. Kevin Kavanagh, Maynooth University; Dr. Tony Morton-Blake, Trinity College Dublin

International
Dr. Pilar López Cornejo, University of Seville; Dr. Eva Enyedy, University of Szeged 
Dr. Nora Negeny, University of Budapest; Prof. Ivelina Georgieva, Bulgarian Academy of Sciences, Prof. Marcos Perez, University of Rio de Janeiro; Prof. Craig Butts, University of Bristol

Industrial
Glanbia; Bimeda; Takeda; Henkel-Loctite; Ipsen Manufacturing Ireland Ltd; Nuritas; ICHEC; Connexicon

  1. G. Sánchez-Sanz, D. Crowe, A. Nicholson, A. Fleming, E. Carey, F. Kelleher, “Conformational studies of Gram-negative bacterial quorum sensing acyl homoserine lactone (AHL) molecules: the importance of the n→* interaction”, BioPhys Chem. 2018, 238, 16-21.
  2. K. Manzor, K ó Proinsias and F. Kelleher, Tetrahedron Letters 2017, 58, 2959-2963.
  3. D. Crowe, A. Nicholson, A. Fleming, E. Carey, G. Sánchez-Sanz, F. Kelleher, “Conformational studies of Gram-negative bacterial quorum sensing 3-oxo N-acyl homoserine lactone molecules”, Bioorg. Med. Chem. 2017, 25, 4285-4296.
  4. D. Karcz, A. Matwijczuk, B. Boroń, B. Creaven, Leszek Fiedor, Andrzej Niewiadomy, Mariusz Gagoś  Journal of Molecular Structure 2017 1128,  44-50.
  5. M. Devocelle, S. McClean, BS Creaven, et al. Organic & Biomolecular Chemistry, 2016, 14, 9278–9286.
  6. J. Ward, L. Li, F. Regan, M. Deasy, F. Kelleher. J. Incl. Phenom. Macrocycl. Chemistry 2015, 83, 377-386.

Nanjing University of Technology, April 2018. Presentation at the first Bilateral Workshop between IT Tallaght and NJUT; Hosted two Erasmus research visitors from School of Pharmacy, University of Leipzig, Germany and two form University of Montpellier, France; Hosted RCSI PhD student for 3 months as part of BioAT, Structured PhD Programme

NDA with Connexion, Surgical Glue Company for a potential product using compounds synthesised within the MDS group; Three Invention Disclosures from SFI project.

  • Founding and administration of AMR Ireland (AntiMicrobial Resistance Ireland)
  • SciFest – Secondary schools science competition
  • Science Week initiatives
  • Tallaght Health Days with Tallaght Hospital
  •  AMR Information Day – Tallaght, April 2018
  • Hosted jointly with TCD the SCI/RSC/ICI funded one day meeting on Supramolecular Chemistry
  • Organized multi-disciplinary industrial conferences with Dr. David Birkett (SCI - Society of Chemical Industry, and Henkel Ireland), with ITT as a venue (e.g. 3D-printing 31 August 2017)
  • Organised COST Meeting In Carlton House, July 2015 on Biomimetic Radical Chemistry
  • Organising Committee of 35th European Peptide Symposium to take place in DCU, August 2018
  • Joint Academic Director of MiCRA – Enterprise Ireland Technology Gateway in IT Tallaght
  • Delivery of Level 10 PhD modules for Structured PhD programme in TU4D alliance
  • Extensive experience in supervision of postgraduate and post-doctoral level researchers
  • Extensive experience as External Examiners at Levels 6-10 for Institutions throughout the island of Ireland
  • Extensive experience as Journal Reviewers across a wide range of publishers
  • Management Committee level involvement in EU COST Actions
  • Coordination of the National Pharmaceutical Education Centre – responsible for of the industry relationships involved on the Education and training side of the Department of Science.
  • Coordination of the on-site company courses – Pfizer, Alkermes and BMS 
  • School Visits promoting Science