Dr Tao Zhang
Tel: (01) 220 5677
Tao Zhang graduated with First Class Honours from Dublin Institute of Technology with a B.Sc Pharmaceutical Technology (2004), subsequently was awarded with Postgraduate Diploma in Quality Improvement (2006) Ph.D degree in Pharmacy (2010) from Trinity College Dublin (TCD). Following postdoctoral work in TCD, he joined Trino Therapeutics Ltd (formerly Pharmatrin Ltd) in 2011, where he held Senior Chemist and Principal Scientist positions involved in innovative drug discovery research programmes and led drug substance GMP manufacturing campaigns. In 2017, he joined APC Ltd as Team Lead, managed an interdisciplinary team of scientists, engineers and analysts on the development and optimisation of (bio)pharmaceutical processes. After a period as HPAL at the School of Food Science and Environmental Health (SoFSEH) at TU Dublin, he was appointed as Lecturer at SoFSEH in 2018. He lectures to undergraduate students across several programmes in the School, including Pharmaceutical Healthcare, Nutraceuticals in Health and Nutrition, Food Innovation, Environmental Health, Culinary Science and Pharmacy Technician Studies,ranging from first year science to advanced fourth year of BSc research projects. Dr Zhang is currently the second year tutor and work placement coordinator of High Certificate Pharmacy Technician Studies programme and the year tutor of B.Sc General Entry Science.
Dr Zhang’s research interests lie in the area developing novel indane hybrid skeletons with biological activities. His main research interest is to identify and develop a novel class of indane, compounds and further to investigate the binding events of these molecules against drug targets like the G-protein-coupled receptors which are involved directly and indirectly in many disease conditions such as central nervous system, inflammation, cancer etc. He is also interested in identifying bioactive molecules from natural products and investigating traditional herbal medicine for unmet clinical and nutritional needs.
Peer Reviewed Publications
- Chan, K., Frankish, N., Zhang, T., Ece, A., Cannon, A., O'sullivan, J. and Sheridan, H. (2020). Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti‐inflammatory molecule PH46A. Journal of Pharmacy and Pharmacology, 72, 927-937. (DOI: 10.1111/jphp.13269)
- Scalabrino, G., Zhang, T., Frankish, N. and Sheridan, H. (2020). Bioactive indanes: development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and rat plasma and its application to a pharmacokinetic study in dog. Journal of Pharmaceutical and Biomedical Analysis, 179, 1-10. (DOI: 10.1016/j.jpba.2019.113011)
- Zhang, T., Scalabrino, G., Frankish, N. and Sheridan, H. (2018). Bioactive indanes: comparative in vitro metabolism study of PH46A, a new potential anti-inflammatory agent and biosynthesis of its primary metabolite PH132. Drug Metabolism & Toxicology, 9, 1-14. (DOI: 10.4172/2157-7609.1000239)
- Zhang, T., Scalabrino, G., Frankish, N. and Sheridan, H. (2018). Bioactive indanes: Proof of concept study for enantioselective synthetic routes to PH46A, a new potential anti-inflammation agent. Molecules, 23, 1-18. (DOI: 10.3390/molecules23071503)
- Cumming, G., Zhang, T., Scalabrino, G., Frankish, N. and Sheridan, H. (2017). Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-inflammatory Agent. Organic Process Research & Development, 21, 1972-1979. (DOI: 10.1021/acs.oprd.7b00258)
- Nazir, I., Rahman, N., Alvi, Z., Rahman, H., Sendker, J., Zhang, T., Frankish, N. and Sheridan, H. (2017). Erratum: Antidiabetic activities of an LC/MS Fingerprinted aqueous extract of Fagonia cretica L. in preclinical models. Planta Medica, 83, E3. (DOI: 10.1055/s-0043-109620)