The module builds on the students' basic knowledge (from Biology 2) of , proteins, carbohydrates and the analysis of biomolecules. The module provides an introduction to enzymology theory and applications, providing the knowledge required for biotechnology modules in later semesters. The study of integrated cell-mediated responses enables the student to understand and appreciate the integration of cellular functions in both normal and altered states. Examples of biopharmaceutical products are highlighted throughout the module.
Introduction to Proteins
Amino acids - structures, features, classification / Levels of protein structure, structure function relationships and factors influencing protein structure and stability / How proteins work - Lock and Key mechanisms, Induced fit models / Detection and quantitation of proteins
Introduction to Enzymology
Classification of enzymes, co-enzymes and co-factors / Michaelis-Menten kinetics, measurements of activity, specific activity, KM and Vmax / Applications of kinetics and the regulation of enzyme activity / Allosteric enzymes
Cell & Human Biochemistry
Introduction to cell-cell communications and receptor mediated processes / Peptide, protein and steroidal hormones / Biopharmaceutical protein case studies: colony stimulating factors (e.g. EPO), interleukins (e.g. IL-2), growth factors (e.g. EGF), cytokines (e.g. interferons) - modes of action and biomedical applications
Metabolism
Glycolysis / Gluconeogenesis / Integration of metabolism,
Carbohydrates
Simple sugars - aldoses and ketoses - structures and chemical characteristics / Complex carbohydrates - starch, glycans, glycosaminoglycans / Glycosylation of proteins - types, functions
| Module Content & Assessment | |
|---|---|
| Assessment Breakdown | % |
| Other Assessment(s) | 30 |
| Formal Examination | 70 |