Module Overview

Cellular Pathology and Clinical Cytology

This module provides an introduction to the study of cell and tissue morphology. The learner will discover how cells and tissues are handled in diagnostic laboratories. The module will introduce the student to the cell and tissue-based investigations and analysis of disease in Cellular Pathology and Clinical Cytology laboratories. The student will learn the principles and methods of cancer screening in current practice and how they impact on Cellular Pathology and Clinical Cytology laboratories.

Module aim: The aim of this module is to provide students with knowledge and practical experience in the procedures and practices of a cellular pathology and clinical cytology laboratory. Students will gain knowledge of the diagnosis of diseases in selected organ systems

Module Code

BIOL 2208

ECTS Credits


*Curricular information is subject to change
  • Fixation and processing
  • Sample types, types of fixatives, processing methods, microtomy and cryotomy.

    • Morphology

    Introduction to different organ systems and tissue morphology and how to recognize normal tissue structure.

    • Histochemistry

    Haematoxylin and Eosin staining, trichrome, silver and dye chemistry, mucin, carbohydrate, lipid and connective tissue staining.

    • Immunohistochemistry

    Principles of Immunohistochemistry methods and their value as biomarkers in diagnosis, prognosis and therapeutics of disease.

    • Molecular Methods

    In-situ hybridization, PCR, Gene arrays, liquid biopsy.

    • Cytology

    Cervical and diagnostic cytology

    • Cancer screening

    Cancer screening programmes, diagnostics, prognostics and therapeutics of cervical, colonic and breast cancer

    • Safety and Quality control

    Quality management and biohazard precautions

    • Disease investigation

    Pathology and investigation of selected organ systems.

    • Histological and cytological Techniques

    Rat dissection, cell and tissue fixation, processing, embedding and freezing, Microtomy and Cryotomy. Histochemistry and immunohistochemistry of cell and tissue components.

    Preparation and staining of direct smears and cytospin preparations, Cell block preparation, Papanicolaou staining.

Lectures, Tutorials, Laboratory Practicals, workshops, online tools and self directed learning. Attendance at laboratory practical sessions is mandatory.

Module Content & Assessment
Assessment Breakdown %
Formal Examination60
Other Assessment(s)40