This module expands on the information presented in the Molecular Immunology 1 module of stage 2, with emphasis on advanced signalling systems and activation of adaptive immune cells. The student will develop an understanding of the genetic mechanisms responsible for the generation of diversity within the immunoglobulin and T cell receptor populations of the adaptive immune system. The molecular mechanisms of thymic education and the role cytokines in health and disease will be discussed.
The aim of this module is to build on concepts introduced in the first and second stages of the course. Particular emphasis will be placed on the mechanisms responsible for the generation of diversity and self/non-self-recognition within the adaptive immune system. The implications of immune modulation in health and disease will be presented.
The T cell antigen receptor complex.Generation of T and B cell diversity - Variable, joining and diversity gene segments, the rearrangement machinery and junctional diversity.Thymic education and self/non-self discrimination.T and B cell activationGeneral properties of cytokines, their receptors and their role in orchestrating immune responses.Overview of topics covered with special emphasis on the immune system in health and disease.
Practicals will be drawn from the following:Immunofixation electrophoresisELISAComputer simulation of Western blottingFlow cytometryCase studies
Methods used to achieve the module learning outcomes will include lectures, tutorials, laboratory practicals, review publications, student presentations, discussion, case studies, problem-solving exercises, video presentations, project work, self-directed learning and computer-based learning. Attendance at laboratory practicals is mandatory.
|Module Content & Assessment