The aim of this module is to provide knowledge and understanding of molecular biomarkers in cancer pathogenesis, diagnosis, monitoring and therapeutics. The genetic basis of inherited and acquired cancers involving tumour suppressor genes, oncogenes and genomic stability will be discussed, in addition to the contributions of mechanisms such as inflammation and environmental exposures. Students will explore the cellular, molecular and genetic basis of cancer and will cover both the scientific and clinical challenges pertinent to the management of specific cancers. Aspects of cancer investigation from molecular diagnostics to standardised and personalised molecular targeted therapies will also be explored.
Molecular carcinogenesis of inherited and acquired cancers
The role of array analysis and/or gene sequencing in inherited and acquired cancers
Cancer diagnostics including cytological, histological, morphological, immunophenotyping and genetic analysis
Biomarker assays in diagnosis and monitoring of cancer and detection of minimal residual disease.
Current and emerging biomarker assays in diagnosis, prognosis and monitoring of cancer
Targeted therapy – the role of laboratory molecular biomarkers assays in theranostics
Lectures, practicals, workshops, journal clubs, tutorials, student-directed reading and online resources.
|Module Content & Assessment