Module Overview

Clinical Chemistry 1: Pathophysiology and analytes of organ systems, methods and quality

This module is a core module in clinical chemistry, which will provide detailed information on the application of chemical methods in the diagnostic laboratory. Particular emphasis will be placed on the methodological underpinnings of common ‘front-line’ laboratory tests and their role in the support of other diagnostic specialties. The module will look at best practice in the testing and reporting of quality laboratory results and will review the applications and interpretation of these strategies in the diagnosis, monitoring and treatment of disease.

Module Code

BIOL 4210

ECTS Credits


*Curricular information is subject to change

Lecture Programme

  • methodological approaches in clinical chemistry (spectrophotometry, light-scattering methods,
  • immunological approaches, ion selective electrodes, chemical methods, chromatography);
  • principles of selected ‘front-line’ diagnostic tests;
  • principles of differential diagnosis by clinical chemistry and development of algorithms;
  • biochemical investigation of organ systems (e.g. renal, hepatobiliary, cardiac, bone);
  • biochemical investigation of disease states (e.g. Carbohydrates disorders, dyslipidaemia,
  • dysproteinaemia, electrolyte disorders, acid-base disorders);
  • the role of molecular diagnostics in the clinical chemistry laboratory;
  • Quality systems in the clinical chemistry laboratory


The purpose of the workshops is to provide training and know-how in differential diagnosis and evidence-based decision making. These workshops will be ‘case-driven’ and problem based.

Practical Programme:

The practical programme is a based on simulated patients whereby each learner will work with aliquots of plasma from a simulated case study (e.g. acute hepatitis, renal failure, myocardial infarction) throughout the programme. Learners will then analyse the results derived from their own data and the associated clinical information.

Lectures 18hr, Tutorials 4hr, Laboratory Teaching Sessions 14, Workshops 6

Module Content & Assessment
Assessment Breakdown %
Other Assessment(s)100