This module will give the student a detailed knowledge of the disease process, with particular emphasis on molecular and cellular pathological changes and inflammatory changes. The aim of the module is to give the students a detailed understanding of the components and multifactorial nature of the disease process.
Lectures
- Introduction to the cause of disease: genetic, congenital and acquired aspects. Aetiology and influence of patient factors will also be outlined. Variations in disease outcomes.
- Genetic basis of disease. Mendelian inheritance and genetic patterns. Variations in Mendelian disease and complex disease. Implications of cell injury and death for disease states. Cell membrane, organelle and cytoskeletal disorders.
- Inflammation and infectious disease:
Acute inflammation: Vascular changes, exudate and fibrin. Neutrophils and endothelial response.
Mediators of acute inflammation. Systemic response to injury. Chronic inflammation: Organisation and repair mechanisms. Granulomas.
- Immune-mediated diseases: Autoimmunity, allergy, immunodeficiency, acute and chronic rejection, GVHD.
- Neoplasia: An introduction to neoplasia; Dysplasia, benign and malignant growth. Staging and grading. Tumour types. Metastases. Causes of cancer.
Practical sessions will include:
- Critical discussion of disease through student presentation.
Examination of diseased tissues covered in lectures
This module will be delivered in one semester with 45 hours of contact hours divided between lectures, tutorials and practicals.
| Module Content & Assessment | |
|---|---|
| Assessment Breakdown | % |
| Formal Examination | 60 |
| Other Assessment(s) | 40 |