This module reviews the basis of regulation of eukaryotic gene expression and reviews experiments that can be used to evaluate sequences for their ability to regulate gene expression. The module also examines the effects of pathogenic mutations on the expression and function of genes and reviews how genes involved in human diseases can be cloned, how mutations causing these diseases can be identified and evaluates potential developments in the therapy for genetic diseases. The module concludes with a review of the use of bioinformatics and sequence analysis software to retrieve, analyse and design diagnostic tests for sequence alterations.
Regulation of eukaryotic and prokaryotic gene expression
Experimental analysis of DNA sequences for transcriptional regulation capabilities
Technologies associated with identification and cloning genes associated with genetic disorders
Novel approaches to the diagnosis and treatment of genetic disorders including the effects of the mutations on protein function and the challenges involved in detecting the mutations.
Computer workshops on DNA / RNA sequence acquisition and analysis
Workshops on sequence analysis, alignment and mutation detection strategies
Problem based learning approaches to the analysis of current problems in molecular microbiology
Practical programme to include eukaryotic cell culture, transfection of eukaryotic cells, nucleic acid isolation, PCR, RTPCR, qPCR
Lectures, tutorials, Problem Based Learning, computer laboratory workshops and laboratory based practicals
| Module Content & Assessment | |
|---|---|
| Assessment Breakdown | % |
| Other Assessment(s) | 100 |