This module will brief students on the state-of-the-art in contemporary proteomics, genomics, epigenomics and metabolomics, using examples from recent primary literature. The aim of the module is to provide learners with an insight into the forefront of knowledge as applied to molecular and biomedical diagnostics and to develop skills of critical analysis and interpretation.
Types of Omics
What is Omics? History and role of large scale approaches to biology. Overview of Proteomics, Metabolomics, Genomics and Epigenomic approaches
Analytical techniques used to produce Omics data
Analytical techniques used to produce omics data e.g mass-spectrometry, 2-Dimensional Electrophoresis, Chromatography (Ion exchange, Size exclusion, Affinity chromatography): Gas chromatography, NMR, microarrays, DNA methylation microarrays, next generation sequencing technologies
Common omics approaches to data analysis, Use of large-scale approaches: deciphering biology, systems biology, biomarker discovery
This module will employ group-work and peer-to-peer learning, and hands-on workshops in Omics technologies and statistical analysis. Students will develop resources focused on different aspects of Omics, which will be shared through the class. Students will undertake a series of practicals (4 x 3hr practicals to obtain laboratory skills in Omics technologies.
|Module Content & Assessment