This module describes the issues associated with fermentation technology including upstream process, the fermentation process and downstream processing. Scale up considerations are also developed and emerging technologies are also included.
Review of cells
Prokaryotic and Eukaryotic cells. Cell growth kinetics.
Isolation, preservation and improvement of industrialMicro-organisms
Screening programmes for producers of therapeutic agents / antibiotics /pharmacologically active compounds/growth factors. Storage and preservation ofindustrial micro-organisms. The use of various systems for the improvement ofindustrial micro-organisms.
Media for Industrial Fermentations
Defined and complex media. Precursors, inhibitors and inducers. Antifoams. Mediumoptimisation.
Sterilisation
Batch and continuous sterilisation systems. Methods of sterilisation. Nutrientavailability and sterilisation.
Reactor Design Considerations
Basic construction and consideration of various reactor types
Instrumentation and Control of reactors
Measurement and control of process variables.
Scale up of Bioprocesses:
Lab scale. Pilot plant. Production scale. Scale up problems
Case studies and current trends
Biopharmaceutical products produced from microbes using innovative technologies.
Emerging and novel technologies
Disposable technologies. High throughput screening of biological and chemical libraries
| Module Content & Assessment | |
|---|---|
| Assessment Breakdown | % |
| Formal Examination | 70 |
| Other Assessment(s) | 30 |