This module is at an intermediate level and builds on the concepts previously introduced in the first year of the programme. It expands the breadth and depth of the organic chemistry programme in both the theory and practical components of the module.
The aim of the module is to provide the learner with an understanding of reaction mechanisms for a range of transformations, including electrophilic aromatic substitution and nucleophilic substitution of haloalkanes.
The learner will also be provided with an understanding of functional groups, the properties, preparation and reactions of amines, alkanes, alkenes, alkynes, alcohols and ethers. The applications of the reactions of these functional groups, particularly to medicinal and pharmaceutical chemistry, will be emphasised where possible.
The practical element of this module will support and reinforce the concepts discussed and studied in the lectures and will build upon the practical knowledge gained by the student in the first year programme.
Review of IUPAC nomenclature. Properties, preparation and reactions of amines. Properties, preparation and reactions of alkanes, cycloalkanes, alkenes and alkynes.
Properties of benzene and derivatives; aromatic stabilisation and resonance, Hückel's Rule applied to benzenoid and heterocyclic aromatic compounds, polycyclic aromatic hydrocarbons. Electrophilic aromatic substitution (including nitration, sulfonation, halogenation and Friedel-Crafts alkylation). Directing effects of the substituents of benzene. A brief introduction to the concept of synthetic strategy as applied to the synthesis of benzene derivatives, such as the use of functional group interconversions and blocking groups.
Preparation and reactions of haloalkanes, alcohols, ethers, aldehydes and ketones, carboxylic acids and derivatives. Examination of mechanisms for selected organic transformations and prediction of the major product(s) formed. Application of the reactivity of these compounds to the organic synthesis of more complex acyclic, cyclic and aromatic molecules.
Students will learn through lectures, use of computer based learning software (including online quizzes / problem solving), tutorials (in the form of problem solving workshops), and laboratory practicals.
| Module Content & Assessment | |
|---|---|
| Assessment Breakdown | % |
| Formal Examination | 45 |
| Other Assessment(s) | 55 |