This module expands on the student’s knowledge of fundamental immunology by covering innate proteins with roles in pattern recognition. The student will also develop an understanding of the genetic mechanisms responsible for the generation of adaptive immune receptors and the molecules involved in lymphocyte activation. The use of immune proteins in laboratory settings will be discussed in detail.
Lecture programme:
The roles of Toll-like receptors and the complement system in the activation of immune responses.
The pathways responsible for the processing of exogenous and endogenous antigen.
Advanced structure and function of the T cell receptor
Molecular events that result in lymphocyte activation
Molecular events that result in the generation of a diverse adaptive immune repertoire.
The uses of antibodies in laboratory assays.
Laboratory programme:
Advanced analysis of histological sections of primary and secondary lymphoid organs
Isolation of peripheral blood mononuclear cells, cell count and flow cytometric analysis
CH50 assay
ELISA
SPE and IFE
Adhesion molecules
Case studies
Methods used to achieve the module learning outcomes will include lectures, tutorials, laboratory practicals, interpretation of data, case studies, problem-solving exercises, video presentations, self-directed learning and computer-based learning.
| Module Content & Assessment | |
|---|---|
| Assessment Breakdown | % |
| Formal Examination | 60 |
| Other Assessment(s) | 40 |