The aim of this module is to develop and update knowledge in key areas of contemporary cell biology and immunology.
The module will be delivered in a day-release format.
Indicative syllabus
Cell cycle control system: role of cyclin-dependent protein kinases (CDKs) and CDK inhibitory proteins.Control of cell division and growth: effect of mitogens on CDK activity, effects of DNA damage, abnormal proliferation signals.Apoptosis: role of caspases, cell surface death receptors, Bcl2, Inhibitors of apoptosis (IAPs), dysregulation of apoptosis and its contribution to disease (cancer).Ion-channel coupled, G-protein coupled and Enzyme-linked cell surface receptors, intracellular signalling proteins: case study (pattern recognition receptors): Toll-like receptors (MAP kinase and NFκB activation).Gene expression and RNA processing, splicing pathway, role of spliceosome, alternative and aberrant forms of splicing, splice variants as cancer biomarkers.Pattern recognition molecules of the innate immune system e.g. toll-like receptors. MHC class I and II structure, function and antigen processing and presentation.Antigen recognition structures of the adaptive immunity including the TCR and immunoglobulin molecules.Downstream signalling events following receptor engagement within the immune response; failures in these systems and resulting pathology.Lymphocyte function: T cells B cells: subsets and roles in immune responses
Lectures, group work, case studies, tutorials.
| Module Content & Assessment | |
|---|---|
| Assessment Breakdown | % |
| Other Assessment(s) | 100 |