This module aims to provide the student with specialist theory and knowledge needed to: conduct advanced organic synthesis with particular emphasis on drug synthetic pathways; prepare and identify common heterocyclic, natural product systems, including amino acids, peptides and chemical assembly of protein analogues; prepare organometallic and polymeric reagents and identify their breakdown products; design syntheses of multifunctional compounds based on the above compound classes; and identify and analyse compounds associated with fire, gunshot/explosive residues and plastics, through the mechanism of physicochemical concepts.
Heterocyclic Chemistry
Synthesis and reactivity of aromatic heterocyclic ring systems and their applications in drug synthesis, through case studies; Aliphatic heterocycles; Synthesis of Amphetamies and related compound classes; Emerging drugs of abuse.
Natural Product Chemistry
Biosynthesis, isolation and chemical synthesis of natural products used in drugs of abuse including - carbohydrates, steroids, alkaloids and their derivatives.
Drug Design
How drugs are designed - Physicochemical properties, QSAR relationships; Stereochemistry in drugs
Polymer Chemistry
Polymer synthesis - free radical methods; ionic polymerisations; elertropolymerisations; breakdown products of bisphenols and styrene etc. Synthesis of fabric and fibre polymers.
| Module Content & Assessment | |
|---|---|
| Assessment Breakdown | % |
| Other Assessment(s) | 30 |
| Formal Examination | 70 |