The module is designed to deliver a better understanding of the properties and reactions of Carbonyl compounds, Carboxylic acid derivatives, Carbonyl alpha-reactions, Carbonyl condensation reactions and Amines. The module is also designed to develop an ability to interpret spectral data and to build on the knowledge of Organic Chemistry acquired in level 1 by imparting an appreciation of structural interpretation and of Carbonyl group chemistry.
Carbonyl compounds Overview of their structure and preparation. Nucleophilic addition reactions of aldehydes and ketones. Relative reactivity of aldehydes and ketones.Imine and enemine formation. Acetal formation.. Conjugate nucleophilic addition to an a,b- unsaturated carbonyl groups. Carboxylic acid derivatives Mechanism of nucleophilic acyl substitution reactions. Mechanism of esterification, ester hydrolysis by acid and base. Carbonyl alpha-substitution reaction Keto-enol tautomerism. The mechanism of alpha- substituion reactions.. Enolate ion formation. And their reactivity. Amines Mechanism of reductive amination of a ketone. Mechanism of the Hoffman rearrangement of an amide to an amine. Structure determination Mass Spectrometry and the interpretation of a mass spectra. Infrared spectra and their interpretation Nuclear Magnetic Resonance Spectroscopy. Conjugated dienes and UV spectroscopys. Molecular orbitals and conjugated dienes. Electrophilic additions to conjugated dienes Allylic carbocations. The Diels – Alder cycloaddition reaction. Aromaticity Identification and assignment of aromaticity in compounds
Formal lectures using all available visual aids eg. VLE, whiteboard, overheads, and Powerpoint and also practical demonstrations where possible. These lectures will be supplemented by tutorial.
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