This module uses a context based learning approach to drug discovery, using the case of 4-aminoquinoline antimalarial drugs as a case study that was developed by the Royal Society of Chemistry in conjunction with TU Dublin. Through a series of workshops and self-directed group learning, the students will develop a research proposal for a new compound. The proposal will include elements of a structure activity relationship study (SAR), including pharmacodynamics, pharmacokinetics, bioassays, synthesis.
Using a context based case study in antimalarial drug design:
Identify drug targets and drug-target interactions.
Structure activity relationship studies, relationship of functional groups on binding interactions and physiochemical properties.
Drug metabolism and the physicochemical properties of drugs in early stages of drug design, including the use of Lipinski‟s rule of 5 and alternatives to predict oral availability.
Synthetic routes (by chemical modification of a lead compound or de novo synthesis of analogues) to a new 4- aminoquinoline drugs.
Interpreting IC50 data in order to determine the effectiveness of a compound in the context of SAR studies
Types of assays used for the biological evaluation of compounds in the context of SAR studies.
|Module Content & Assessment