16th Annual Graduate Research Symposium at TU Dublin
Our PhD candidate Shengxin Zhang delivered an oral presentation at the 16th Annual Graduate Research Symposium, which hosted by TU Dublin on 19 January 2026. The presentation titled "Exploration of Indane Scaffold Antagonists for Combination Prostate Cancer Therapy with Cold Atmospheric Plasma" systematically introduced the cutting-edge research and development progress of current combination therapy strategies for prostate cancer (PCa).
This research targets the persistent and clinically significant challenge of androgen receptor (AR) antagonists resistance in PCa, with the objective of assessing the therapeutic synergy between small-molecule AR antagonists and cold atmospheric plasma (CAP). In particular, the project investigates indane-based scaffolds as next-generation AR antagonists candidate with the aim of establishing a structurally versatile and optimizable molecular platform for combination PCa therapy.
CAP as an emerging therapeutic approach can generate various active substances under near-room temperature conditions and its reported selective anti-tumour activity against PCa cells, thus attracting widespread attention in the field of tumor treatment research in recent years. This study provides mechanistic insight and translational direction for the optimization and clinical translation of combination therapeutic strategies for PCa.
