Tanno B, Novelli F, Leonardi S, Merla C, Babini G, Giardullo P, Kadhim M, Traynor D, Medipally DKR, Meade AD, Lyng FM, Tapio S, Marchetti L, Saran A, Pazzaglia S, Mancuso M. MiRNA-Mediated Fibrosis in the Out-of-Target Heart following Partial-Body Irradiation. Cancers (Basel). 2022 Jul 16;14(14):3463. doi: 10.3390/cancers14143463
Traynor, D.; Duraipandian, S.; Bhatia, R.; Cuschieri, K.; Tewari, P.; Kearney, P.; D’Arcy, T.; O’Leary, J.J.; Martin, C.M.; Lyng, F.M. Development and Validation of a Raman Spectroscopic Classification Model for Cervical Intraepithelial Neoplasia (CIN). Cancers 2022, 14(7), 1836;https://doi.org/10.3390/cancers14071836
Pazzaglia, S.; Tanno, B.; De Stefano, I.; Giardullo, P.; Leonardi, S.; Merla, C.; Babini, G.; Tuncay Cagatay, S.; Mayah, A.; Kadhim, M.; et al. Micro-RNA and Proteomic Profiles of Plasma-Derived Exosomes from Irradiated Mice Reveal Molecular Changes Preventing Apoptosis in Neonatal Cerebellum. J. Mol. Sci. 2022, 23(4), 2169; https://doi.org/10.3390/ijms23042169
Behl I, Calado G, Vishwakarma A, Traynor D, Flint S, Galvin S, Healy CM, Pimentel ML, Malkin A, Byrne HJ, Lyng FM. Classification of cytological samples from oral potentially malignant lesions through Raman spectroscopy: A pilot study. Spectrochim Acta A Mol Biomol Spectrosc. 2022 Feb 5;266:120437. doi: 10.1016/j.saa.2021.120437
Howe O, White L, Cullen D, O'Brien G, Shields L, Bryant J, Noone E, Bradshaw S, Finn M, Dunne M, Shannon AM, Armstrong J, McClean B, Meade A, Badie C, Lyng FM. A 4-Gene Signature of CDKN1, FDXR, SESN1 and PCNA Radiation Biomarkers for Prediction of Patient Radiosensitivity. Int J Mol Sci. 2021 Sep 30;22(19):10607. doi: 10.3390/ijms221910607
Traynor D, Behl I, O'Dea D, Bonnier F, Nicholson S, O'Connell F, Maguire A, Flint S, Galvin S, Healy CM, Martin CM, O'Leary JJ, Malkin A, Byrne HJ, Lyng FM. Raman spectral cytopathology for cancer diagnostic applications. Nat Protoc. 2021. DOI: 10.1038/s41596-021-00559-5.
Howe O, Lyng FM, Mothersill C. Women's contributions to radiobiology in Ireland; from small beginnings……. Int J Radiat Biol. 2021 1-37. DOI: 10.1080/09553002.2021.1931529.
Pazzaglia S, Tanno B, Antonelli F, Giardullo P, Babini G, Subedi P, Azimzadeh O, Khan ZN, Oleksenko K, Metzger F, Toerne CV, Traynor D, Medipally D, Meade AD, Kadhim M, Lyng FM, Tapio S, Saran A, Mancuso M. Out-of-Field Hippocampus from Partial-Body Irradiated Mice Displays Changes in Multi-Omics Profile and Defects in Neurogenesis. Int J Mol Sci. 2021 Apr 20;22(8):4290. DOI: 10.3390/ijms22084290
Traynor D, Martin CM, White C, Reynolds S, D'Arcy T, O'Leary JJ, Lyng FM. Raman Spectroscopy of Liquid-Based Cervical Smear Samples as a Triage to Stratify Women Who Are HPV-Positive on Screening. Cancers (Basel). 2021 Apr 22;13(9):2008. DOI: 10.3390/cancers13092008
Calado G, Behl I, Byrne HJ, Lyng FM, Raman spectroscopic characterisation of non stimulated and stimulated human whole saliva, Clinical Spectroscopy, 2021, 3, 100010, https://doi.org/10.1016/j.clispe.2021.100010
Neha Chaudhary, Thi Nguyet Que Nguyen, Muddassar Ahmad, Robert Harrington, Caroline A. Jefferies, Grainne Kearns, Aidan D. Meade, Claire Wynne, A spectroscopic diagnostic for rheumatoid arthritis using liquid biopsies, Clinical Spectroscopy, 3, 2021, 100009, https://doi.org/10.1016/j.clispe.2021.100009.
N. Chaudhary, T.N.Q. Nguyen, A. Maguire, C. Wynne, A.D. Meade (2021). Comparison of sample preparation methodologies towards optimisation of Raman spectroscopy for peripheral blood mononuclear cells. Anal. Methods, https://doi.org/10.1039/D0AY02040K.
Chaudhary, D. Cullen, AD Meade, C. Wynne, Discrimination of immune cell activation using Raman micro-spectroscopy in an in-vitro & ex-vivo model, Spectrochimica Acta Part A: Mol. Biomol. Spec., 2021 DOI: 10.1016/j.saa.2020.119118
TNQ Nguyen, A. Maguire, C. Mooney, N. Jackson, N. Lynam Lennon, V. Weldon, A.A. Maguire, C.Muldoon, N. Ravi, J.V. Reynolds, J. O’Sullivan, D. Meade, Prediction of pathological response to neo-adjuvant chemoradiotherapy for oesophageal cancer using vibrational spectroscopy, Translational Biophotonics,2021 DOI: 10.1002/tbio.202000014
Conway, G.E.; Zizyte, D.; Mondala, J.R.M.; He, Z.; Lynam, L.; Lecourt, M.; Barcia, C.; Howe, O.; Curtin, J.F. Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells. Pharmaceuticals2021, 14, 91. https://doi.org/10.3390/ph14020091
Ibrahim O, Toner M, Flint S, Byrne HJ, Lyng FM. The Potential of Raman Spectroscopy in the Diagnosis of Dysplastic and Malignant Oral Lesions. Cancers (Basel). 2021 13(4):619. DOI: 10.3390/cancers13040619.
Byrne HJ, Behl I, Calado G, Ibrahim O, Toner M, Galvin S, Healy CM, Flint S, Lyng FM. Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics. Spectrochim Acta A Mol Biomol Spectrosc. 2021 252:119470. doi: 10.1016/j.saa.2021.119470.
O'Loughlin, J., Napolitano, S., Alkhathami, F., O'Beirne, C., Marhöfer, D., O'Shaughnessy, M., Howe, O., Tacke, M. and Rubini, M. (2021), The Antibacterial Drug Candidate SBC3 is a Potent Inhibitor of Bacterial Thioredoxin Reductase. ChemBioChem. https://doi.org/10.1002/cbic.202000707
O’Shaughnessy, M.; McCarron, P.; Viganor, L.; McCann, M.; Devereux, M.; Howe, O. The Antibacterial and Anti-Biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas aeruginosafrom Irish Cystic Fibrosis Patients. Antibiotics 2020, 9, 674. https://doi.org/10.3390/antibiotics9100674
Awatif Rashed Z. Almotairy, Diego Montagner, Liam Morrison, Michael Devereux, Orla Howe, Andrea Erxleben. Pt(IV) pro-drugs with an axial HDAC inhibitor demonstrate multimodal mechanisms involving DNA damage and apoptosis independent of cisplatin resistance in A2780/A2780cis cells, Journal of Inorganic Biochemistry, Volume 210, 2020, 111125, ISSN 0162-0134, https://doi.org/10.1016/j.jinorgbio.2020.111125.
Gandra Rafael M., McCarron Pauraic, Viganor Livia, Fernandes Mariana Farias, Kavanagh Kevin, McCann Malachy, Branquinha Marta H., Santos André L. S., Howe Orla, Devereux Michael. In vivo Activity of Copper(II), Manganese(II), and Silver(I) 1,10-Phenanthroline Chelates Against Candida haemulonii Using the Galleria mellonella Model. Frontiers in Microbiology. 11, 2020: 470. DOI=10.3389/fmicb.2020.00470
Gillian E. Conway, Deimante Zizyte, Julie Rose Mae Mondala, Zhonglei He, Lorna Lynam, Mathilde Lecourt, Carlos Barcia, Orla Howe, James F Curtin. Ursolic acid inhibits cell migration and promotes JNK-dependent lysosomal associated cell death in Glioblastoma multiforme cells. bioRxiv 2020.03.11.987578; DOI: https://doi.org/10.1101/2020.03.11.987578
Garret Rochford, Zara Molphy, Kevin Kavanagh, Malachy McCann, Michael Devereux, Andrew Kellett, Orla Howe. Cu(II) phenanthroline–phenazine complexes dysregulate mitochondrial function and stimulate apoptosis, Metallomics, Volume 12, Issue 1, January 2020, Pages 65–78, https://doi.org/10.1039/c9mt00187e
Chaudhary, C. Wynne, A.D. Meade, A review of applications of Raman spectroscopy in Immunology, Biomed. Spec. Imag. DOI 10.3233/BSI-200198 (2020).
Guo S, Beleites C, Neugebauer U, Abalde-Cela S, Afseth NK, Alsamad F, Anand S, Araujo-Andrade C, Aškrabić S, Avci E, Baia M, Baranska M, Baria E, Batista de Carvalho LAE, de Bettignies P, Bonifacio A, Bonnier F, Brauchle EM, Byrne HJ, Chourpa I, Cicchi R, Cuisinier F, Culha M, Dahms M, David C, Duponchel L, Duraipandian S, El-Mashtoly SF, Ellis DI, Eppe G, Falgayrac G, Gamulin O, Gardner B, Gardner P, Gerwert K, Giamarellos-Bourboulis EJ, Gizurarson S, Gnyba M, Goodacre R, Grysan P, Guntinas-Lichius O, Helgadottir H, Grošev VM, Kendall C, Kiselev R, Kölbach M, Krafft C, Krishnamoorthy S, Kubryck P, Lendl B, Loza-Alvarez P, Lyng FM, Machill S, Malherbe C, Marro M, Marques MPM, Matuszyk E, Morasso CF, Moreau M, Muhamadali H, Mussi V, Notingher I, Pacia MZ, Pavone FS, Penel G, Petersen D, Piot O, Rau JV, Richter M, Rybarczyk MK, Salehi H, Schenke-Layland K, Schlücker S, Schosserer M, Schütze K, Sergo V, Sinjab F, Smulko J, Sockalingum GD, Stiebing C, Stone N, Untereiner V, Vanna R, Wieland K, Popp J, Bocklitz T. Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study. Anal Chem. 2020 Dec 15;92(24):15745-15756. doi: 10.1021/acs.analchem.0c02696.
Tuncay Cagatay S, Mayah A, Mancuso M, Giardullo P, Pazzaglia S, Saran A, Daniel A, Traynor D, Meade AD, Lyng F, Tapio S, Kadhim M. Phenotypic and Functional Characteristics of Exosomes Derived from Irradiated Mouse Organs and Their Role in the Mechanisms Driving Non-Targeted Effects. Int J Mol Sci. 2020 Nov 9;21(21):8389. DOI: 10.3390/ijms21218389
Behl I, Calado G, Vishwakarma A, Flint S, Galvin S, Healy CM, Pimentel ML, Malkin A, Byrne HJ, Lyng FM, Raman microspectroscopic study for the detection of oral field cancerisation using brush biopsy samples, Journal of Biophotonics 2020 DOI:1002/jbio.202000131
Behl I, Calado G, Malkin A, Flint S, Galvin S, Healy CM, Pimentel ML, Byrne HJ, Lyng FM, A pilot study for early detection of oral premalignant diseases using oral cytology and Raman microspectroscopy: Assessment of confounding factors, Journal of Biophotonics 2020 DOI:1002/jbio.202000079
Cullen D, Bryant J, Maguire A, Medipally DKR, McClean B, Shields L, Noone E, Bradshaw S, Finn M, Dunne M, Shannon AM, Armstrong J, Howe O, Meade AD, Lyng FM. Raman spectroscopy of lymphocytes for the identification of prostate cancer patients with late radiation toxicity following radiotherapy, Translational Biophotonics 2 (4) e201900035 2020 https://doi.org/10.1002/tbio.201900035
Medipally DKR, Cullen D, Untereiner V, Bryant J, Sockalingum GD, Nguyen TNQ,, Noone E, Bradshaw S, Finn M, Dunne M, Shannon AM, Armstrong J, Meade AD, Lyng FM. Effect of hemolysis on Fourier transform infrared and Raman spectra of blood plasma. J. Biophotonics. 2020;e201960173. https://doi.org/10.1002/jbio.201960173
Medipally DKR, Cullen D, Untereiner V, Bryant J, Sockalingum GD, Maguire A, Nguyen TNQ, Bryant J, Noone E, Bradshaw S, Finn M, Dunne M, Shannon AM, Armstrong J, Meade AD, Lyng FM. Vibrational spectroscopy of liquid biopsies for prostate cancer diagnosis, Ther Adv Med Oncol 2020, Vol. 12: 1–23, DOI:10.1177/1758835920918499
Bryant, J., White, L., Coen, N., Shields, L., McClean, B., Meade, A. D., Lyng, F. M. and Howe, O. MicroRNA Analysis of ATM-Deficient Cells Indicate PTEN and CCDN1 as Potential Biomarkers of Radiation Response. Radiat. Res. 193, 000–000 (2020).
Stefano Fornasaro, Fatima Alsamad, Monica Baia, Luís A. E. Batista de Carvalho, Claudia Beleites, Hugh J. Byrne, Alessandro Chiadò, Mihaela Chis, Malama Chisanga, Amuthachelvi Daniel, Jakub Dybas, Gauthier Eppe, Guillaume Falgayrac, Karen Faulds, Hrvoje Gebavi, Fabrizio Giorgis, Royston Goodacre, Duncan Graham, Pietro La Manna, Stacey Laing, Lucio Litti, Fiona M. Lyng, Kamilla Malek, Cedric Malherbe, Maria P. M. Marques, Moreno Meneghetti, Elisa Mitri, Vlasta Mohaček-Grošev, Carlo Morasso, Howbeer Muhamadali, Pellegrino Musto, Chiara Novara, Marianna Pannico, Guillaume Penel, Olivier Piot, Tomas Rindzevicius, Elena A. Rusu, Michael S. Schmidt, Valter Sergo, Ganesh D. Sockalingum, Valérie Untereiner, Renzo Vanna, Ewelina Wiercigroch, Alois Bonifacio, Surface Enhanced Raman Spectroscopy for Quantitative Analysis: Results of a Large-Scale European Multi-Instrument Interlaboratory Study Chem.2020, 92, 5, 4053-4064 https://doi.org/10.1021/acs.analchem.9b05658
Grogan, C.; Amarandei, G.; Lawless, S.; Pedreschi, F.; Lyng, F.; Benito-Lopez, F.; Raiteri, R.; Florea, L. Silicon Microcantilever Sensors to Detect the Reversible Conformational Change of a Molecular Switch, Spiropyan. Sensors2020, 20,https://doi.org/10.3390/s20030854
White L, Shields L, Howe O, Vega Carrascal I, Maguire A, Meade A, McClean B, Lyng FM, A Comparison of Radiobiological Response in Cells Exposed to Low LET Radiation with Different Beam Energies. Radiation Environment and Medicine 2020 9 (1) 1–6
Carvalho LFC, Dos Santos L, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Neto LP, Martin AA, Lyng FM, Byrne HJ. Can ethanol affect the cell structure - a dynamic molecular and Raman spectroscopy study. Photodiagnosis Photodyn Ther. 2020 101675. DOI: 10.1016/j.pdpdt.2020.101675.
Declan O’Dea, Fiona M. Lyng, Siobhan Nicholson, Finbar O'Connell, Aoife Maguire, Alison Malkin, Recent advances in the vibrational spectroscopic diagnosis of non-small cell lung cancer, Vibrational Spectroscopy, 2019, 104, 102946, https://doi.org/10.1016/j.vibspec.2019.102946.
Medipally DKR, Nguyen TNQ, Bryant J, Untereiner V, Sockalingum GD, Cullen D, Noone E, Bradshaw S, Finn M, Dunne M, Shannon AM, Armstrong J, Lyng FM, Meade AD. Monitoring Radiotherapeutic Response in Prostate Cancer Patients Using High Throughput FTIR Spectroscopy of Liquid Biopsies. Cancers (Basel). 2019 Jul 2;11(7). pii: E925. doi: 10.3390/cancers11070925
J. Bryant, L.Shields, C. Hynes, O. Howe, B. McClean, and F. Lyng DNA Damage and Cytokine Production in Non-Target Irradiated Lymphocytes, Radiation Research 191(6), 545-555 https://doi.org/10.1667/RR15165.1
Lyng FM, Traynor D, Nguyen TNQ, Meade AD, Rakib F, Al-Saady R, Goormaghtigh E, Al-Saad K, Ali MH (2019) Discrimination of breast cancer from benign tumours using Raman spectroscopy. PLoS ONE 14 (2): e0212376. https://doi.org/10.1371/journal. pone.0212376
Traynor D, Duraipandian S, Bhatia R, Cuschieri K, Martin CM, O'Leary JJ, Lyng FM. The potential of biobanked liquid based cytology samples for cervical cancer screening using Raman spectroscopy. J Biophotonics 2019 https://doi.org/10.1002/jbio.201800377
S. Duraipandian, D. Traynor, P. Kearney, C. Martin, J.J. O’Leary, F.M. Lyng, Raman spectroscopic detection of high-grade cervical cytology: Using morphologically normal appearing cells. Sci Rep 2018 8(1):15048
O'Dea D, Bongiovanni M, Sykiotis GP, Ziros PG, Meade AD, Lyng FM and Malkin A. Raman spectroscopy for the preoperative diagnosis of thyroid cancer and its subtypes: An in vitro proof‐of‐concept study. Cytopathology. 2019;30:51–60. https://doi.org/10.1111/cyt.12636
Aidan D. Meade, Adrian Maguire, Jane Bryant, Daniel Cullen, Dinesh Medipally, Lisa White, Brendan McClean, Laura Shields, John Armstrong, Mary Dunne, Emma Noone, Shirley Bradshaw, Marie Finn, Aoife M. Shannon, Orla Howe & Fiona M. Lyng (2019) Prediction of DNA damage and G2 chromosomal radio-sensitivity ex vivo in peripheral blood mononuclear cells with label-free Raman micro-spectroscopy, International Journal of Radiation Biology, DOI: 10.1080/09553002.2018.1451006
Gillian E Conway, Zhonglei He, Ana Lacramioara Hutanu, George Paul Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T Murray, Patrick J Cullen, James F Curtin Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells. Sci Rep9, 12891 (2019). https://doi.org/10.1038/s41598-019-49013-3
Galdino Anna Clara M., Viganor Lívia, de Castro Alexandre A., da Cunha Elaine F. F., Mello Thaís P., Mattos Larissa M., Pereira Marcos D., Hunt Mary C., O’Shaughnessy Megan, Howe Orla, Devereux Michael, McCann Malachy, Ramalho Teodorico C., Branquinha Marta H., Santos André L. S. Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target. Frontiers in Microbiology. 10, 2019: 1701. DOI=10.3389/fmicb.2019.01701
Louise MacLean, Dariusz Karcz, Hollie Jenkins, Siobhán McClean, Michael Devereux, Orla Howe, Marcos D. Pereira, Nóra V. May, Éva A. Enyedy, Bernadette S. Creaven. Copper(II) complexes of coumarin-derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?Journal of Inorganic Biochemistry, Volume 197, 2019, 110702. https://doi.org/10.1016/j.jinorgbio.2019.110702.
Dina Tolan, Awatif Rashed Z. Almotairy, Orla Howe, Michael Devereux, Diego Montagner, Andrea Erxleben, Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid. Inorganica Chimica Acta, Volume 492, 2019, Pages 262-267, https://doi.org/10.1016/j.ica.2019.04.038.
Reynolds A., Giltrap M., Chambers G, Evaluation of non-invasive toxicological analysis of nano-polystyrene in relative in vivo conditions to D. magna, Environmental Sciences Nano, 2019. DOI: 10.1039/c9en00434c
Ó Fearghail, M. Giltrap, C. O’Connor, P. Behan, Improving Extraction Processes of Crustacean Chitin Using Solid State Analytical Techniques.SSRG International Journal of Applied Chemistry 2019 6(2), 23-30, 2019.
Jella KK, Moriarty R, McClean B, Byrne HJ, Lyng FM (2018) Reactive oxygen species and nitric oxide signaling in bystander cells. PLoS ONE 13(4): e0195371. https://doi.org/10.1371/journal.pone.0195371
Mohamed H. Ali, Fazle, Rakib, Khalid Al-Saad, Rafif Al-Saady, Fiona M. Lyng, Erik Goormaghtigh, A simple model for cell type recognition using 2D-correlation analysis of FTIR images from breast cancer tissue, Journal of Molecular Structure, 2018 1163, 472-479
Traynor D, Duraipandian S, Martin CM, O'Leary JJ, Lyng FM. Improved removal of blood contamination from ThinPrep cervical cytology samples for Raman spectroscopic analysis J Biomed Opt. 2018 23(5):1-8. DOI: 10.1117/1.JBO.23.5.055001
Traynor D, Kearney P, Ramos I, Martin CM, O'Leary JJ, Lyng FM. A study of hormonal effects in cervical smear samples using Raman spectroscopy. J Biophotonics. 2018 11(6):e201700240. DOI: 10.1002/jbio.201700240
Vibe Jakobsen, Livia Viganor, Alfonso Blanco-Fernández, Orla Howe, Michael Devereux, Christine J. McKenzie, Vickie McKee. Tetrameric and polymeric silver complexes of the omeprazole scaffold; synthesis, structure, in vitro and in vivo antimicrobial activities and DNA interaction, Journal of Inorganic Biochemistry, Volume 186, 2018, Pages 317-328, https://doi.org/10.1016/j.jinorgbio.2018.05.018.
Garret Rochford, Zara Molphy, Niall Browne, Carla Surlis, Michael Devereux, Malachy McCann, Andrew Kellett, Orla Howe, Kevin Kavanagh. In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes, Journal of Inorganic Biochemistry, https://doi.org/10.1016/j.jinorgbio.2018.05.020.
Carron, Pauraic M.; Crowley, Aisling; O'Shea, Denis; McCann, Malachy; Howe, Orla; Hunt, Mary; Devereux, Michael. Targeting the Folate Receptor: Improving Efficacy in Inorganic Medicinal Chemistry. Current Medicinal Chemistry, Volume 25, Number 23, 2018, pp. 2675-2708(34). DOI: https://doi.org/10.2174/0929867325666180209143715
Farhane, Z., Bonnier, F., Howe, O., Casey, A. and Byrne, H.J. (2018), Doxorubicin kinetics and effects on lung cancer cell lines using in vitroRaman micro‐spectroscopy: binding signatures, drug resistance and DNA repair. J. Biophotonics, 11: e201700060. https://doi.org/10.1002/jbio.201700060
Patange, A., Boehm, D., Giltrap M, Lu, P., Cullen, P.J., Bourke, P. 2018. Assessment of the disinfection capacity and ecotoxicological impact of cold plasma for treatment of food industry effluents.Science of the total environment, 631, 298-307.
